, if a patient is getting clonidine hydrochloride as well as likewise taking tricyclic antidepressants the hypotensive effects of clonidine might be decreased.
As a result of a possibility for additive results such as bradycardia and AV block, care is called for in people getting clonidine concomitantly with representatives recognized to affect sinus nodule function or AV nodal transmission (e. g. digitalis, calcium network blockers and beta-blockers).
Use caution when clonidine hydrochloride extended-release tablet computers are provided concomitantly with antihypertensive medicines, due to the possibility for additive pharmacodynamic effects (e. g. hypotension, syncope) [see Warnings and Precautions (5.
Pregnancy Category C: Oral administration of clonidine hydrochloride to expecting rabbits throughout the period of embryo/fetal organogenesis at doses of up to 80 mcg/kg/day (about 3 times the dental max suggested day-to-day dose [MRHD] of 0.4 mg/day on a mg/m2 basis) generated no proof of embryotoxic or teratogenic possibility. In expectant rats, nevertheless, doses as low as 15 mcg/kg/day (1/3 the MRHD on a mg/m2 basis) were connected with raised tractions in a study in which dams were treated continually from 2 months prior to mating and throughout pregnancy. Enhanced resorptions were not connected with therapy at the same or at greater dosage levels (approximately 3 times the MRHD) when treatment of the dams was restricted to gestation days 6-15. Increases in tractions were noted in both rats as well as mice at 500 mcg/kg/day (10 and 5 times the MRHD in rats and mice, respectively) or higher when the animals were treated on gestation days 1-14; 500 mcg/kg/day was the most affordable dosage employed in this study. No well-controlled and sufficient researches have actually been performed in expecting ladies. This drug ought to not be made use of throughout pregnancy unless clearly required since animal duplication researches are not constantly predictive of human feedback.